Endometriosis and assisted reproductive techniques independently related to mother–child morbidities: a French longitudinal national study

Research question Does endometriosis increase obstetric and neonatal complications, does assisted reproductive technology (ART) cause additional risk of maternal or fetal morbidity? Design A nationwide cohort study (2013–2018) comparing perinatal morbidities in three groups single pregnancies: spontaneous pregnancies without endometriosis; with ART women endometriosis. Results Mean ages were 30.0 (SD = 5.3), 31.7 4.8) 33.1 years 4.0), for conceptions, conceptions groups, respectively (P < 0.0001). Comparison conceptions: independently increased the venous thrombosis (adjusted OR [aOR] 1.51, P 0.001), pre-eclampsia (aOR 1.29, placenta previa 2.62, placental abruption 1.54, premature birth 1.37, small gestational age 1.05, 0.001) malformations 1.06, 0.049). endometriosis: 2.43, 95% CI 2.10 to 2.82, 1.42, 1.29 1.55, 1.18, 1.10 1.27, from effect Risk pre-eclampsia, congenital was not ART. Conclusion Endometriosis is an independent factor mother child morbidities. Maternal morbidity significantly by addition however, some risks increasingly linked pathologies related infertility.